Improved gas-liquid chromatographic method for measurement of mexiletine in plasma.
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چکیده
منابع مشابه
Improved liquid-chromatographic determination of mexiletine, an antiarrhythmic drug, in plasma.
In this improved reversed-phase liquid-chromatographic procedure for determination of mexiletine in plasma, mexiletine and an internal standard, chlorodisopyramide, are extracted with methylene chloride from 0.5 mL of serum or plasma; the extract is then concentrated and injected onto a C18 chromatographic column. Mexiletine in the column effluent is detected by monitoring absorbance at 210 nm....
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Mexiletine, l-methyl-Z(2,6-xylyloxy)ethylamine hydrochloride (Mexitil@ ), has been shown to suppress markedly ventricular rhythm disorders [l61. Effective serum levels of mexiletine range from ca. 0.5 to 2.0 pg/ml [24,7,8]. Although the antiarrhythmic efficacy of mexiletine is not correlated directly with its serum level [ 3,4,7,8], the determination of the drug is recommended when adverse effe...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1982
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/28.1.245